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Leaving Cert Biology: Immune system

How often Immune system comes up on the Biology papers, every year it was asked, and questions to try.

HL Asked on 6 of the last 10 Higher Level papers, most recently in 2025. most years

OL Asked on 3 of the last 10 Ordinary Level papers, most recently in 2026.

June 2027 is the first exam on the new Biology course. These come from the 2016–2026 papers, so read them as a guide.

Immune system, Higher Level(6 marks)

Quick ones on Immune system.

(a)Proteins made against a specific antigen?
  1. Antibiotics
  2. Antibodies
  3. Hormones
(b)White blood cells that engulf microorganisms?
  1. B lymphocytes
  2. Platelets
  3. Phagocytes
(c)T cells that destroy virus-infected body cells?
  1. Killer T cells
  2. Suppressor T cells
  3. Helper T cells
Show the answers

(a) Antibodies

(b) Phagocytes

(c) Killer T cells

Your turn: Higher Level questions on Immune system.

Higher Level

Asked on 6 of the last 10 Higher Level papers, most recently in 2025. most years

Every paper, year by year

YearWhere it came up
2026Not asked
2025Q16
2024Q16
2023Q16
2022Q5, Q7
2021Q16
2019Not asked
2018Not asked
2017Q14
2016Not asked

Links open the State Examinations Commission’s paper for that year.

More Immune system questions

Immune system, 2 marks

White cells that kill virus-infected and cancer cells without needing to have met them before?

  1. Helper T cells
  2. B lymphocytes
  3. Natural killer cells
Show the answer

Natural killer cells

Natural killer cells are part of the innate response. Killer T cells do a similar job but only after they have been activated by a specific antigen.

Ordinary Level

Asked on 3 of the last 10 Ordinary Level papers, most recently in 2026.

Every paper, year by year

YearWhere it came up
2026Q16
2025Q17
2024Not asked
2023Not asked
2022Not asked
2021Not asked
2019Not asked
2018Q14
2017Not asked
2016Not asked

Links open the State Examinations Commission’s paper for that year.

More Immune system questions

Immune system, 2 marks

Which blood cells defend the body against infection?

  1. Red blood cells
  2. Platelets
  3. White blood cells
Show the answer

White blood cells

White cells engulf germs or make antibodies against them. Red cells only carry oxygen.

Immune system, 3 marks

What are the proteins made by white blood cells to fight germs called?

  1. Antibiotics
  2. Antibodies
  3. Antigens
Show the answer

Antibodies

Antibodies are made by the body. Antigens are the foreign markers on the germ, and antibiotics are medicines made from micro-organisms.

Immune system, 2 marks

Giving a weakened or dead form of a pathogen to produce immunity is called?

  1. Vaccination
  2. A blood transfusion
  3. Antibiotic treatment
Show the answer

Vaccination

The vaccine is harmless but the body still makes antibodies and memory cells, so the real disease is fought off quickly later.

Other Biology topics

All of Leaving Cert Biology